Pentobarbital will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of abiraterone by affecting hepatic/intestinal enzyme... https://bbsocialclub.com/story22396003/poco-conosciuto-fatti-circa-pentobarbital-natrium