TAK-243 preferentially sure to UBA1 more than the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened amounts of ubiquitylated proteins, increased markers of proteotoxic pressure and DNA destruction strain. In vivo, TAK-243 reduced leukemic stress and targeted leukemic stem cells without https://bobq531jpt5.ageeksblog.com/profile